Vygon’s Vadsite and Bionector Meet the MHRA Safety Alert (DSI/2025/02) for Safer IV Therapy

Important Product Update July 2025: MRHA Alert (DSI/2025/02)

MRHA Alert:

Aurum pre-filled syringes phased introduction of new 10ml CONNECT syringe barrel: Importance of selecting compatible needle-free connectors to minimise the risk of syringe blockage (DSI/2025/02)

Due to a phased introduction of the new 10ml CONNECT barrel design for the Aurum pre-filled syringes, the range of compatible needle-free connectors (NFCs) differs between the established syringe barrel and the new syringe barrel. It is vital that healthcare professionals use compatible NFCs with Aurum pre-filled syringes to prevent delays to delivery of emergency medication.

For users of Vygon’s Vadsite and Bionector needle-free connectors, Vygon can confirm these devices are fully aligned with the latest recommendations from the Medicines and Healthcare products Regulatory Agency (MHRA), reinforcing its commitment to patient safety and infection prevention in intravenous (IV) therapy.

Product Guidance and Compatibility

During the phased introduction and transition period of the two Aurum pre-filled syringes, users of Vygon’s needle-free connectors should be aware of the following product guidance and compatibility:

• Vadsite, Vygon’s negative displacement reliable needle-free connector, is fully compatible with both versions of the Aurum pre-filled syringes.
• Bionector:
  • With the Legacy Aurum syringes, the adaptor (ATP431) is needed. Please see guidance below for use.
  • With the new CONNECT syringes, Bionector can be used without any adaptors.

For a comprehensive overview of compatible devices, please refer to the Aurum connector compatibility chart

Instructions for use: Universal Adaptor, Bionector and legacy Aurum syringes

1. Attach the universal adaptor to the Bionector
2. Insert pre-filled glass emergency syringe (Aurum) into end of adaptor, then bolus as normal
3. Remove the adaptor following administration of emergency drug(s).

*If an adaptor is unavailable, remove the Bionector/extension set and access the cannula directly.

Healthcare professionals can be confident that Vadsite and Bionector offer, not only ease of use and reliability, but also, the assurance of regulatory compatibility, helping to maintain the highest standards of care across NHS and private healthcare settings.